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Distinct Role of Surface Lymphotoxin Expressed by B Cells in the Organization of Secondary Lymphoid Tissues

✍ Scribed by Alexei V. Tumanov; Dmitry V. Kuprash; Maria A. Lagarkova; Sergei I. Grivennikov; Koichiro Abe; Alexander N. Shakhov; Ludmila N. Drutskaya; Colin L. Stewart; Alexander V. Chervonsky; Sergei A. Nedospasov

Book ID
117723273
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
618 KB
Volume
17
Category
Article
ISSN
1074-7613

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Lymphotoxin-alpha (LTalpha) was originally linked to delayed-type hypersensitivity and its production was later attributed to Th1, but not Th2 cells. Studies employing knockout mice demonstrated that LT signaling is essential for the development and functional compartmentalization of lymphoid tissue