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Distinct requirements for activation-induced cell surface expression of preformed Fas/CD95 ligand and cytolytic granule markers in T cells

✍ Scribed by Kassahn, D; Nachbur, U; Conus, S; Micheau, O; Schneider, P; Simon, H-U; Brunner, T


Book ID
109841027
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
354 KB
Volume
16
Category
Article
ISSN
1350-9047

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## Abstract Cells from the CD4^+^ murine T hybridoma line IP‐12‐7 enter the apoptotic suicide program via the Fas ligand (FasL)/Fas‐mediated pathway upon TCR stimulation. This stimulus regulates the sensitization of the Fas death pathway and the cell surface appearance of preformed FasL. The apopto