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Distinct Regulation of pH in the Cytosol and in Acidic Organelles by a Subunit Isoforms of V-ATPase in Human Cancer Cells

✍ Scribed by Sennoune, Souad R.; Hinton, Ayana; Bond, Sarah; Forgac, Michael; Martinez-Zaguilan, Raul


Book ID
119205236
Publisher
Biophysical Society
Year
2009
Tongue
English
Weight
85 KB
Volume
96
Category
Article
ISSN
0006-3495

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## Abstract DAPK1, a ca^+2^/calmodulin regulated serine/threonine kinase, is a major tumor suppressor, whose expression is lost in multiple tumor types. However, the mechanisms contributing to it are unclear. We have recently shown that CCAAT/Enhancer binding protein‐β (C/EBP‐β) is required for the