Distinct pattern of TP53 mutations in squamous cell carcinoma of the esophagus in Iran
✍ Scribed by Hainaut, Pierre; Sepehr, Alireza; Tanière, Philippe; Martel-Planche, Ghislaine; Zia'ee, Abed-Ali; Rastgar-Jazii, Ferdous; Yazdanbod, Mansour; Etemad-Moghadam, Gholamreza; Kamangar, Farin; Saidi, Farrokh
- Book ID
- 110066489
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 48 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0950-9232
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The mutational spectrum for the TP53 gene was investigated in a large series of bladder tumors and bladder tumor cell lines. Tumors and cell lines were screened for the presence of TP53 point mutations by single-strand conformational polymorphism analysis followed by direct sequencing. Mutations wer
## Abstract In an attempt to correlate the __TP53__ mutation pattern of squamous cell carcinomas of the esophagus (ESCC) and life style factors of patients from the high risk area Rio Grande do Sul, Brazil, 135 ESCC were analyzed, after prescreening by p53 immunohistochemistry, by SSCP and DNA sequ