Distinct pathogenic processes between Fig4-deficient motor and sensory neurons

Severe peripheral sensory neuron loss an

Severe peripheral sensory neuron loss and modest motor neuron reduction in mice with combined deficiency of brain-derived neurotrophic factor, neurotrophin 3 and neurotrophin 4/5

✍ Xin Liu; Rudolf Jaenisch 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 500 KB

Neurotrophins are a family of structurally and functionally related proteins that regulate neuronal survival during development. In the peripheral nervous system (PNS), both in vitro and in vivo studies have shown that neurotrophins are potent factors for the survival of various sensory neurons and