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Distinct molecular origins for Denys-Drash and Frasier syndromes

✍ Scribed by F. Poulat; D. Morin; A. König; P. Brun; J. Giltay; C. Sultan; R. Dumas; M. Gessler; P. Berta


Publisher
Springer
Year
1993
Tongue
English
Weight
368 KB
Volume
91
Category
Article
ISSN
0340-6717

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WT1 mutations in patients with Denys-Dra
✍ Agneta Nordenskjöld; Eitan Friedman; Maria Anvret 📂 Article 📅 1994 🏛 Springer 🌐 English ⚖ 803 KB

Denys-Drash syndrome (DDS) is characterized by early onset nephropathy, pseudohermaphroditism in males and a high risk for developing Wilm's tumour (WT). The exact cause of DDS is unknown but germline mutations in the Wilm's tumour suppressor gene (WT1) have recently been described in the majority o