Distinct mechanisms of Taxol-induced serine phosphorylation of the 66-kDa Shc isoform in A549 and RAW 264.7 cells

Taxol induces tyrosine phosphorylation o

Taxol induces tyrosine phosphorylation of SHC and its association with GRB2 in murine raw 264.7 cells

✍ Marina Wolfson; Chia-Ping Huang Yang; Susan Band Horwitz 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 81 KB

Taxol, a natural product with significant anti-tumor activity, stabilizes microtubules and arrests cells in the G2/M phase of the cell cycle. It has been reported that taxol has additional effects in cells, including an increase in tyrosine phosphorylation of proteins and activation of MAP kinase. W