Distinct kimberlite pipe classes with contrasting eruption processes

An endogenously processed self peptide a

An endogenously processed self peptide and the corresponding exogenous peptide bound to the same MHC class II molecule could be distinct ligands for TCR with different kinetic stability

✍ Takahiro Gyotoku; Yoshinori Fukui; Takehiko Sasazuki 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 242 KB

Immunization with self peptides often elicits activation of CD4 + T cells in vivo. Although such peptides have been suggested to be derived from minor self determinants or self antigens sequestered from the immune system, we found that immunization with E § peptide (E § 52-68), a major self determin