Distinct immunologic features of finnish Sjögren's syndrome patients with HLA alleles DRB1*0301, DQA1*0501, and DQB1*0201. Alterations in circulating T cell receptor γ/δ subsets
✍ Scribed by Tuija O. Kerttula; Pekka Collin; Anne Polvi; Markku Korpela; Jukka Partanen; Markku Mäki
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 672 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
✦ Synopsis
To determine whether there were differences in the circulating T lymphocyte subsets or clinical features of patients with primary Sjogren's syndrome (SS) who were positive for different HLA alleles.
Methods. Twoand three-color flow cytometry analyses were performed, using a whole blood lysing method.
Results. Patients with SS who had the HLA alleles DRB1*0301, DQA1*0501, and DQB1*0201 had lower levels of circulating VS1-positive T cell receptor y/S (TCRy/G) cells and higher levels of circulating CD45RO-positive TCRyIG cells compared with patients with SS who did not have these alleles. The patient subgroup with these alleles also had higher levels of anti-SS-A/Ro and anti-SS-B/La.
Conclusion.
These results indicate that patients with primary SS may be immunologically divided into subgroups according to their HLA status. These immunologic changes in SS may also be typical of other