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Distinct actions of Akt1 and Akt2 in skeletal muscle differentiation

✍ Scribed by Peter Rotwein; Elizabeth M. Wilson


Book ID
102315192
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
463 KB
Volume
219
Category
Article
ISSN
0021-9541

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## Abstract Akt1 and Akt2 are the major isoforms of Akt expressed in muscle cells and muscle tissue. We have performed siRNA silencing of Akt1 and Akt2 in C2 myoblasts to characterize their specific implication in muscle differentiation. Whereas silencing Akt2, and not Akt1, inhibited cell cycle ex