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Distichiasis-lymphedema syndrome: Tetralogy of Fallot, chylothorax, and neonatal death

✍ Scribed by Chen, Emily; Larabell, Susan K.; Daniels, Jamilyn M.; Goldstein, Stanley


Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
266 KB
Volume
66
Category
Article
ISSN
0148-7299

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✦ Synopsis


W e describe a newborn female with a severe presentation of distichiasis-lymphedema syn- drome (McKusick 15340). She was initially evaluated because of a phenotype suggestive of Ullrich-Turner or Noonan syndrome (low posterior hairline, cupped ears, severe pterygium colli, heart murmur, and pectus excavatum). Distichiasis was noted at age 6 weeks. Subsequent to surgery for tetralogy of Fallot, patent ductus arteriosus, and branch pulmonic stenosis, she developed persistent chylothorax and sepsis. She died at 3 months. Family history indicated segregation of distichiasis-lymphedema syndrome. She was the sixth member in her family to have this disorder and was the most severely affected. @