3-Substituted GABA analogs with central
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Justin S. Bryans; David J. Wustrow
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Article
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1999
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John Wiley and Sons
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English
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Gabapentin and Pregabalin are both 3-alkylated โฅ-amino butyric acid (GABA) analogs. Gabapentin was designed as a lipophilic GABA analog and was first synthesized as a potential anticonvulsant and was launched in 1994 as add-on therapy for the treatment of epilepsy. In this review the discovery and d