Dissolution studies on ampicillin embonate and amoxycillin embonate

✍ Scribed by Tarja Saesmaa; Ann Marie Tötterman

• Book ID: 103911279
• Publisher: Elsevier Science
• Year: 1990
• Tongue: English
• Weight: 446 KB
• Volume: 8
• Category: Article
• ISSN: 0731-7085
• DOI: 10.1016/0731-7085(90)80007-c

✦ Synopsis

The dissolution behaviour of slightly water-soluble embonic acid salts of ampicillin and amoxycillin was studied quantitatively as a function of solution pH (1.15-8.00) using the rotating disk method combined with reversed-phase high-performance liquid chromatography. The dissolution rate of ampicillin embonate was greater than that of amoxycillin embonate at all pH values investigated. The graphs of pH-intrinsic rate of dissolution of the antibiotics from the salts were U-shaped, the minimum being close to the respective isoelectric points of the parent antibiotics. Embonic acid was not detectable below pH 5; above pH 5 the dissolution rate of embonic acid increased as a function of pH.