Dissolution behavior and bioavailability
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Keiji Yamamoto; Masahiro Nakano; Takaichi Arita; Yoshikazu Takayama; Yoshinobu N
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Article
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1976
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John Wiley and Sons
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English
β 557 KB
The ground mixture of phenytoin and microcrystalline cellulose was prepared by grinding in a vibrational ball mill. The X-ray diffraction patterns indicated the amorphous nature of the ground mixture. Comparative studies were made concerning the in vitro dissolution and in vivo absorption of fine ph