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Dissolution kinetics of griseofulvin in mixed micellar solutions

✍ Scribed by Jan H. De Smidt; Mustafa Grit; Daan J. A. Crommelin

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
511 KB
Volume
83
Category
Article
ISSN
0022-3549

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✦ Synopsis

The dissolution kinetics of the poorly water soluble, lipophilic model drug substance griseofulvin were studied in solutions containing simple and mixed micelles of sodium cholate (BS) and phosphatidylcholine (PC). Variables under investigation were the concentration of BS and the ratio PUBS. A rotating disk apparatus was used to monitor the dissolution process. With this method, (mixed) micellar diffusion coefficients could be calculated and some detailed information about the physicochemical behavior and composition of mixed PUBS micelles could be derived.

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