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Dissolution Enhancement of a Drug Exhibiting Thermal and Acidic Decomposition Characteristics by Fusion Processing: A Comparative Study of Hot Melt Extrusion and KinetiSol® Dispersing

✍ Scribed by Justin R. Hughey; James C. DiNunzio; Ryan C. Bennett; Chris Brough; Dave A. Miller; Hua Ma; Robert O. Williams; James W. McGinity

Book ID: 111768172
Publisher: Springer US
Year: 2010
Tongue: English
Weight: 918 KB
Volume: 11
Category: Article
ISSN: 1530-9932
DOI: 10.1208/s12249-010-9431-y

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Fusion processing of itraconazole solid dispersions by kinetisol® dispersing: A comparative study to hot melt extrusion

✍ James C. DiNunzio; Chris Brough; Dave A. Miller; Robert O. Williams III; James W 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 287 KB

KinetiSol Dispersing (KSD) is a novel high energy manufacturing process investigated here for the production of pharmaceutical solid dispersions. Solid dispersions of itraconazole (ITZ) and hypromellose were produced by KSD and compared to identical formulations produced by hot melt extrusion (HME).