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Dissolution and in vivo evidence of differences in reference products: impact on development of generic drugs

โœ Scribed by Michael Spino; Yu Chung Tsang; Radu Pop

Publisher
Springer-Verlag
Year
2000
Tongue
English
Weight
741 KB
Volume
25
Category
Article
ISSN
0378-7966

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With the extensive use of different strains of mice and rats in in vivo efficacy models, lack of relevant metabolic clearance data among strains has been a concern. Metabolic clearance is an important parameter impacting drug discovery, and it is often used as a compound selection filter. Metabolica