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Dissociation of recombinant tumor necrosis factor-α studied by gel permeation chromatography

✍ Scribed by Linda Owers Narhi; Tsutomu Arakawa


Book ID
115760598
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
364 KB
Volume
147
Category
Article
ISSN
0006-291X

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A phase I study withrecombinant human tumor necrosis factor a (rhuTNF-a; Knoll AG, Ludwigshafen, FRG) in patients with advanced malignant disease was undertaken to evaluate drug toxicity (organ specifity, time course, predictability, reversibility, maximal tolerated dose), effectiveness, antigenicit