Dissociation of interleukin-2-mediated cell proliferation and interleukin-2 receptor upregulation in adult T-cell leukemia cells
โ Scribed by Toshiyuki Hori; Takashi Uchiyama; Hiroshi Umadome; Shigeki Tamori; Mitsuru Tsudo; Koichi Araki; Haruto Uchino
- Book ID
- 113238518
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- English
- Weight
- 636 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0145-2126
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Stimulation of T cells by the T-cell receptor (TCR)/CD3 complex results in interleukin-2 (IL-2) synthesis and surface expression of the IL-2 receptor (IL-2R), which in turn drive T-cell proliferation. However, the significance of the requirement of IL-2 in driving T-cell proliferation, when TCR stim
## Dissociation of interleukin 2-dependent and -independent B cell proliferation with monoclonal anti-interleukin 2 receptor antibody* In a recent report from our laboratory (J. Exp. Med. 1984. 160: 1070), it has been shown that B cells which have been activated with lipopolysaccharide (LPS) plus