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Dissociation of Hepatic Steatosis and Insulin Resistance in Mice Overexpressing DGAT in the Liver

✍ Scribed by Mara Monetti; Malin C. Levin; Matthew J. Watt; Mini P. Sajan; Stephen Marmor; Brian K. Hubbard; Robert D. Stevens; James R. Bain; Christopher B. Newgard; Robert V. Farese Sr.; Andrea L. Hevener; Robert V. Farese Jr.

Book ID
116372554
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
661 KB
Volume
6
Category
Article
ISSN
1550-4131

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In this study, we investigated the role of acyl-coenzyme A:diacylglycerol acyltransferase 2 (DGAT2) in glucose and lipid metabolism in obese mice by reducing its expression in liver and fat with an optimized antisense oligonucleotide (ASO). High-fat diet-induced obese (DIO) C57BL/6J mice and ob/ob m