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Dissemination of Mycobacterium tuberculosis Is Influenced by Host Factors and Precedes the Initiation of T-Cell Immunity

✍ Scribed by Chackerian, A. A.; Alt, J. M.; Perera, T. V.; Dascher, C. C.; Behar, S. M.

Book ID
121848159
Publisher
American Society for Microbiology
Year
2002
Tongue
English
Weight
627 KB
Volume
70
Category
Article
ISSN
0019-9567

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## Abstract Definition of protective immunity induced by effective vaccines is important for the design of new pathogen control strategies. Inactivation of the PhoP response‐regulator in __Mycobacterium tuberculosis__ results in a highly attenuated strain that demonstrates impressive protective eff