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Disseminated follicular eruption during therapy with the MEK inhibitor AZD6244

✍ Scribed by Christiane Querfeld; Keith Duffy; George Magel; Darryl Oble; Ezra E.W. Cohen; Christopher R. Shea


Book ID
116585763
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
791 KB
Volume
64
Category
Article
ISSN
1097-6787

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## Abstract Mutations in __KRAS__ or __BRAF__ frequently manifest in constitutive activation of the MEK1/2‐ERK1/2 signalling pathway. The MEK1/2‐selective inhibitor, AZD6244 (ARRY‐142886), blocks ERK1/2 activation and is currently undergoing clinical evaluation. Tumour cells can vary markedly in th