Computer simulations of the properties o
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Andrzej Sikorski; Andrzej Kolinski; Jeffrey Skolnick
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Article
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2000
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John Wiley and Sons
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English
⚖ 286 KB
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Reduced lattice models of the three de novo designed helical proteins ␣ 2 , ␣ 2 C, and ␣ 2 D were studied. Low temperature stable folds were obtained for all three proteins. In all cases, the lowest energy folds were four-helix bundles. The folding pathway is qualitatively the same for all proteins