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Dissection of signaling pathways and cloning of new signal transducers in tyrosine kinase-induced pathways by genetic selection

โœ Scribed by Mahlmann, S; McLaughlin, J; Afar, D E H; Mohr, R; Kay, R J; Witte, O N


Book ID
110054147
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
207 KB
Volume
13
Category
Article
ISSN
0887-6924

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To investigate how mechanical loading stimulates bone cells, we subjected murine osteoblast-like cells, MC3T3E1, to fluid flow generated by shaking culture dishes. Since we had previously found that egr-1 mRNA is up-regulated by the flow, and that the regulation involves tyrosine kinase, we examined