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Dissecting the transcription networks of a cell using computational genomics

โœ Scribed by Hao Li; Wei Wang


Book ID
116504845
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
132 KB
Volume
13
Category
Article
ISSN
0959-437X

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## Abstract Amplification of the oncogenic transcription factor __MYCN__ plays a major role in the pathogenesis of several pediatric cancers, including neuroblastoma, medulloblastoma, and rhabodomyosarcoma. For neuroblastoma, __MYCN__ amplification is the most powerful genetic predictor of poor pat