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Dissecting p53 tumor suppressor function in vivo through the analysis of genetically modified mice

✍ Scribed by Johnson, T M; Attardi, L D

Book ID
110017202
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
195 KB
Volume
13
Category
Article
ISSN
1350-9047

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## Abstract Deletion of the tumor suppressor gene p53 has been shown to improve the outcome in experimental models of focal cerebral ischemia and kainate‐induced seizures. To evaluate the potential role of p53 in traumatic brain injury, genetically modified mice lacking a functional p53 gene (p53^–