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Dissecting DNA-Histone Interactions in the Nucleosome by Molecular Dynamics Simulations of DNA Unwrapping

โœ Scribed by Ettig, Ramona; Kepper, Nick; Stehr, Rene; Wedemann, Gero; Rippe, Karsten


Book ID
119209083
Publisher
Biophysical Society
Year
2011
Tongue
English
Weight
937 KB
Volume
101
Category
Article
ISSN
0006-3495

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In eukaryote nucleosome, DNA wraps around a histone octamer in a left-handed way. We study the process of chirality formation of nucleosome with Brownian dynamics simulation. We model the histone octamer with a quantitatively adjustable chirality: left-handed, right-handed or non-chiral, and simulat