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Disruption of the antioxidant shield in fibroblasts from Werner syndrome

✍ Scribed by García-Giménez⁎, J.L.; Spis, M.; Seco, M.; Velázquez-Ledesma, A.M; Pérez-Quilis, C.; Pallardó et al, F.V.

Book ID
122501331
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
60 KB
Volume
53
Category
Article
ISSN
0891-5849

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The Werner syndrome (WS) is a segmental progeroid syndrome caused by a recessive mutation (WRN) mapped to 8p12. The replicative life spans of somatic cells cultured from WS patients are substantially reduced compared to agematched controls. Certain molecular concomitants of the replicative decline o