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Disruption of the 12/15-Lipoxygenase Gene (Alox15) Protects Against Denervation-Induced Muscle Atrophy

✍ Scribed by Arunabh Bhattacharya; Amanda L. Jernigan; Marian Sabia; Yiqiang Zhang; Yan Li; Wenbo Qi; Holly Van Remmen

Book ID
113632502
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
53 KB
Volume
51
Category
Article
ISSN
0891-5849

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Disruption of the 12/15-lipoxygenase gen
Disruption of the 12/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease
✍ Marcos Martínez-Clemente; Natàlia Ferré; Esther Titos; Raquel Horrillo; Ana Gonz 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 849 KB

We have shown that Alox15, the gene encoding for 12/15-lipoxygenase (12/15-LO), is markedly up-regulated in livers from apolipoprotein E-deficient (ApoE 2/2 ) mice, which spontaneously develop nonalcoholic fatty liver disease secondary to hyperlipidemia. In the current study, we used ApoE 2/2 mice w