Chronic lymphocytic leukemia (B-CLL) and mantle cell lymphoma (MCL) share many features and their differential diagnosis may be challenging, especially when a leukemic picture alone is present. Monoclonal antibody panels are often useful, with CD23 being the most reliable. However, MCL diagnosis sho
Disruption of T cell suppression in chronic lymphocytic leukemia by CD200 blockade
β Scribed by Christian P. Pallasch; Sabine Ulbrich; Reinhild Brinker; Michael Hallek; Robert A. Uger; Clemens-Martin Wendtner
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 317 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0145-2126
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
B-cell chronic lymphocytic leukemia (B-CLL) is characterized by the accumulation of mature-appearing clonal B cells exhibiting coexpression of CD5 and CD23. In addition to the accumulation of neoplastic B cells, numerous T-cell abnormalities also occur in B-CLL patients. In this study, the presence,
B-cell chronic lymphocytic leukemia (B-CLL) is characterized by the slow and progressive accumulation of monoclonal apparently mature, CD5 Ψ B lymphocytes. The majority of circulating cells appear to be nondividing, and it has been suggested that a prolonged life span is mainly responsible for the a
## Abstract Deletion of chromosome region 11q22βq23 defines a subgroup of patients with Bβcell chronic lymphocytic leukemia (BβCLL) characterized by poor survival. Although the tumorβsuppressor gene __ATM__ in the consensus deletion region was found to be biallelically inactivated in about one thir