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Disruption of protein phosphatase 2A subunit interaction in human cancers with mutations in the Aα subunit gene

✍ Scribed by Ruediger, Ralf; Pham, Huong T; Walter, Gernot

Book ID
110064364
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
158 KB
Volume
20
Category
Article
ISSN
0950-9232

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Protein phosphatase 2A (PP2A) consists of 3 subunits: the catalytic subunit, C, and the regulatory subunits, A and B. The A and C subunits both exist as 2 isoforms (␣ and ␤) and the B subunit as multiple forms subdivided into 3 families, B, B and B؆. It has been reported that the genes encoding the