Disruption of p73-MDM2 binding synergizes with gemcitabine to induce apoptosis in HuCCT1 cholangiocarcinoma cell line with p53 mutation

Mutation of p53 in head and neck squamou

Mutation of p53 in head and neck squamous cell carcinoma correlates with Bcl-2 expression and increased susceptibility to cisplatin-induced apoptosis

✍ Genevieve A. Andrews; Sichuan Xi; Rebecca G. Pomerantz; Charles J. Lin; William 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 515 KB

## Abstract ## Background. The p53 protein, a well‐known tumor suppressor that functions primarily as a transcription factor, initiates cell cycle arrest and apoptosis after genotoxic stress. The antiapoptotic regulator Bcl‐2 is a downstream modulator of p53‐induced apoptosis. Loss of function of