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Disruption of bone development and homeostasis by trisomy in Ts65Dn Down syndrome mice

✍ Scribed by Joshua D. Blazek; Anna Gaddy; Rachel Meyer; Randall J. Roper; Jiliang Li


Book ID
116323633
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
592 KB
Volume
48
Category
Article
ISSN
8756-3282

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Mouse genetic models can be used to dissect molecular mechanisms that result in human disease. This approach requires detection and demonstration of compelling parallels between phenotypes in mouse and human. Ts65Dn mice are at dosage imbalance for many of the same genes duplicated in trisomy 21 or