Parallels of craniofacial maldevelopment
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Joan T. Richtsmeier; Laura L. Baxter; Roger H. Reeves
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Article
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2000
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John Wiley and Sons
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English
β 251 KB
π 1 views
Mouse genetic models can be used to dissect molecular mechanisms that result in human disease. This approach requires detection and demonstration of compelling parallels between phenotypes in mouse and human. Ts65Dn mice are at dosage imbalance for many of the same genes duplicated in trisomy 21 or