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Disruption of actin microfilaments by cytochalasin D leads to activation of p53

โœ Scribed by S.N Rubtsova; R.V Kondratov; P.B Kopnin; P.M Chumakov; B.P Kopnin; J.M Vasiliev


Book ID
117109352
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
216 KB
Volume
430
Category
Article
ISSN
0014-5793

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Disruption of actin organization by cyto
โœ M V St-Pierre; J Dufour; I M Arias ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 301 KB

The bile canaliculi of hepatocytes contract spontaneously, and it is hypothesized that this canalicular motility provides a propulsive force for normal intrahepatic bile flow. Cytochalasin disrupts actin polymerization, inhibits contraction, and decreases bile flow. We investigated whether this chol