Disrupted Schwann cell–axon interactions in peripheral nerves of mice with altered L1-integrin interactions

Nerve growth factor-hypersecreting Schwa

Nerve growth factor-hypersecreting Schwann cell grafts augment and guide spinal cord axonal growth and remyelinate central nervous system axons in a phenotypically appropriate manner that correlates with expression of L1

✍ Weidner, N.; Blesch, A.; Grill, R.J.; Tuszynski, M.H. 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 838 KB

Schwann cells contribute to efficient axonal regeneration after peripheral nerve injury and, when grafted to the central nervous system (CNS), also support a modest degree of central axonal regeneration. This study examined (1) whether Schwann cells grafted to the CNS exhibit normal patterns of diff