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Disrupted recycling of the low density lipoprotein receptor by PCSK9 is not mediated by residues of the cytoplasmic domain

✍ Scribed by Thea Bismo Strøm; Øystein L. Holla; Kristian Tveten; Jamie Cameron; Knut Erik Berge; Trond P. Leren


Book ID
116989007
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
705 KB
Volume
101
Category
Article
ISSN
1096-7192

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Degradation of the LDL receptors by PCSK
✍ Øystein L Holla; Jamie Cameron; Knut Erik Berge; Trine Ranheim; Trond P Leren 📂 Article 📅 2007 🏛 BioMed Central 🌐 English ⚖ 506 KB

## Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) post-transcriptionally degrades the low density lipoprotein receptors (LDLR). However, it is unknown whether PCSK9 acts directly on the LDLR or if PCSK9 activates another protein that in turn causes degradation of the LDLR. ## Res