Degradation of the LDL receptors by PCSK
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Øystein L Holla; Jamie Cameron; Knut Erik Berge; Trine Ranheim; Trond P Leren
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Article
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2007
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BioMed Central
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English
⚖ 506 KB
## Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) post-transcriptionally degrades the low density lipoprotein receptors (LDLR). However, it is unknown whether PCSK9 acts directly on the LDLR or if PCSK9 activates another protein that in turn causes degradation of the LDLR. ## Res