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Disposition of premazepam, an anti-anxiety pyrrolodiazepine, in the cynomolgus monkey

โœ Scribed by G. Zanolo; M C. Giachetti; S. Canali; A. Bernareggi; G. Tarzia; A. Assandri


Book ID
113006565
Publisher
Springer-Verlag
Year
1986
Tongue
English
Weight
992 KB
Volume
11
Category
Article
ISSN
0378-7966

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Pharmacokinetic disposition of the novel
โœ Gregory M. Kochak; Ashok Rakhit; Frank Honc; C. James Mahoney ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› Springer ๐ŸŒ English โš– 385 KB

The intravenous pharmacokinetic disposition of the novel, atypical anxiolytic CGS 9896 was studied in six cynomolgus monkeys. CGS 9896 was infused at dose levels of approximately 60, 120, and 240 ~tg/h/kg for a duration of 12 h, resulting in steady-state plasma concentrations averaging 38.4, 51.8, a