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Disposition of nitrofurantoin and nitrofurazone in the isolated perfused rat kidney

โœ Scribed by Betty-Ann Hoener; Terry Ray Krueger

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
367 KB
Volume
73
Category
Article
ISSN
0022-3549

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โœฆ Synopsis

Disposition of Nitrofurantoin and Nitrofurazone in the lsolated Perfused Rat Kidney

Keyphrases 0 Nitrofurantoin-renal metabolism, isolated perfused rat kidney 0 Nitrofurazone-renal metabolism, isolated perfused rat kidney

To the Editor:

Nitrofurantoin is frequently used clinically to treat urinary tract infections, but little is known of its renal metabolism. The side effects of nitrofurantoin therapy, pulmonary and hepatic toxicities, and polyneuropathies, are thought to be a consequence of its reductive metabolic activation (1 -5).

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