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Disposition of morphine and its glucuronide metabolites after oral and rectal administration: Evidence of route specificity

✍ Scribed by Babul, Najib; Darke, Andrew C


Book ID
109845206
Publisher
Nature Publishing Group
Year
1993
Tongue
English
Weight
982 KB
Volume
54
Category
Article
ISSN
0009-9236

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The disposition of morphine (MOR) and its metabolites in the rabbit was measured after topical administration of its hydrochloride salt (MOR. HCI), and their time course was compared with those after intravenous and oral administration. The area under the plasma concentration-time curve (AUC) ratio