Disposition of Human Drug Preparations in the Horse. V. Orally Administered Oxprenolol
✍ Scribed by F. T. Delbeke
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 376 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0269-3879
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✦ Synopsis
Urinary concentrations of the Pantagonist oxprenolol and some of its major human metabolites were determined following oral administration of a dose of 160 mg to five fasted horses. Quantitation was performed by gas chromatography-mass spectrometry (CC-MS) in the selected ion mode (SIM) by monitoring ion d z 466 of the heptafluorobutyric derivatives. As early as 2 h after dosage oxprenolol could be detected in hydrolysed urine and remained detectable up to 24 h. Maximum urinary concentrations and excretion rates were obtained between 2 and 12 h. After 12 h only 2.8% of the administered dose was excreted as conjugates of oxprenolol and major human metabolites including 4-OH-oxprenolol and 5-OH-oxprenolol. These metabolites were detectable up to 48 h.