The physicochemical and biopharmaceutical properties, such as pK a , crystal habit, water solubility, logD, molecular structure and dynamics, and membrane permeability of CR3124 (endo-2-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-2,3-dihydro-1Hbenz[e]isoindol-1-one, a novel potent 5-HT 3 receptor antagon
Disposition of 8-methyl-8-azabicyclo[3,2,1]octan-3-yl 3,5-dichlorobenzoate, a potent 5-hydroxytryptamine antagonist, and two metabolites in dogs and monkeys
β Scribed by Haiyung Cheng; Douglas L. Larsen; Jonathan A. Ragner; G. Douglas Sproles; W. Perry Gordon
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 377 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Two new natural products, N- (2-methyl-3-oxodec-8-enoyl)corresponding acid chloride, in order to acylate Meldrum's acid. Subsequent aminolysis with pyrrolidine, followed by 2-pyrroline (2) and 2-(hept-5-enyl)-3-methyl-4-oxo-6,7,8,8atetrahydro-4H-pyrrolo[2,1-b]-1,3-oxazine (3), have been methylation
0 (6R,7R)-7-[2-(5-Amir1o-l,2,4-thiadiazol9-yl)-(Z)-2-methoxyiminoacetamid]-3-[(4-carbamoyl-1 -quinuclidinio)methylJ-8-oxo-5thia-1 -azabicyclo [4,2,0]oct-2-ene-2-carboxylate (1 ; E l 040) was isolated as a-(decahydralte), p-(pentahydrate), and yform (anhydrate) crystals and the X-ray amorphous form.
The metabolism of SCH 40120, which is the clinically effective antipsoriatic drug 10- (3chlorophenyl)-6,8,9,10-tetrahydrobenzol[b][1,8]naphthyridin-5(7H)-one, was determined in vitro. Rat, dog, cynomolgus monkey, and human liver slices hydroxylated the aliphatic, cyclohexenyl ring of the drug and co