## Abstract A stereospecific highβperformance liquid chromatographic (HPLC) method was developed for the quantitation of the enantiomers of venlafaxine, an antidepressant, in dog, rat, and human plasma. The procedure involves derivatization of venlafaxine with the chiral reagent, (+)βSβnaproxen chl
Disposition kinetics of ML-1035 sulfoxide enantiomers and the prochiral sulfide in rats
β Scribed by Be-Sheng Kuo; James C. Poole; Arun K. Mandagere; Kin-Kai Hwang
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 716 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0899-0042
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The disappearance from plasma and the excretion in bile of the monoquaternary thiazinamium (administered as the iodide) and one of its polar metabolites, thiazinamium sulfoxide (also administered as the iodide), were studied in the rat after intravenous injection to obtain more information on hepati
The effects of ibuprofen on maternal phenytoin pharmacokinetics and fetal phenytoin acquisition were investigated in 19-day gestation Sprague-Dawley rats. A 5 mg kg-' bolus injection of I4C-phenytoin was given with and without (control) pretreatment with 12.5 mg kg-' of ibuprofen. Maternal plasma an
Solute absorption from the airways was compared and modeled in vivo and in vitro isolated perfused rat lung (IPRL), and its regional kinetic descriptors in the presence of competing mucociliary escalator were estimated. 7.4 kDa Β―uorophorelabeled polyhydroxyethylaspartamide (F-PHEA), FITC-labeled dex