Disposition kinetics and distribution of demeclocycline in various biological fluids in female goats

✍ Scribed by V. K. Jha; C. Jayachandran; M. K. Singh

• Book ID: 104639455
• Publisher: Springer Netherlands
• Year: 1989
• Tongue: English
• Weight: 384 KB
• Volume: 13
• Category: Article
• ISSN: 0165-7380
• DOI: 10.1007/bf00142048

✦ Synopsis

Jha, V.K., Jayachandran, C. and Singh, M.K. 1989. Disposition kinetics and distribution of demeclocycline in various biological fluids in female goats. Veterinary Research Communications, 13 (3), 22.5-230

A pharmacokinetic study of demeclocycline was carried out following intravenous administration at 5 mg/kg body weight in lactating goats. Demeclocycline appeared within 5 min in plasma, interstitial fluid (isf) and urine, while it appeared at 1 h in milk. Peak concentrations of 21.70 + 4.06, 2.67 + 0.23, 5.6.5 + 0.45 and 82.23 + 10.06 pg/ml were attained at 5 min and at 6, 8 and 8 h in plasma, isf, milk and urine respectively. A potentially therapeutic concentration of 20.5 pg/ml was maintained from 5 min-36 h, 30 min-30 h, l-36 h and 5 min-48 h in plasma, isf, milk and urine respectively. The drug was detectable in all the above biological fluids for at least 48 h. A low distribution half life (tr p) of 0.44 -C 0.04 h and a high elimination half life (tt 28) of 19.24 + 1.22 h denote rapid distributt6n but very slow elimination of the drug in goats. A hi& tissue plasma concentration ratio [K :(K -@)I of 5.12 2 0.97 during the elimination phase and a Vdaea of 1.59 + 0.18 L/kg ind#ate%niform distribution of demeclocycline in the tissues atd body fluids of goats. The dosage regimen for maintaining minimum plasma concentration (C ti = MIC) of 0.5, 1.0 and 1.5 kg/ml at selected dosage intervals of 12 and 24 h was also calculated. Ktywordk goat, pharmacology, blood, urine, milk, drugs, antibiotics, demeclocycline