✦ LIBER ✦

DISPOSITION DECOMPOSITION ANALYSIS FOR PHARMACODYNAMIC MODELING OF THE LINK COMPARTMENT

✍ Scribed by Haiyung Cheng; William J. Jusko

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 351 KB
Volume: 17
Category: Article
ISSN: 0142-2782
DOI: 10.1002/(sici)1099-081x(199603)17:2<117::aid-bdd949>3.0.co;2-a

No coin nor oath required. For personal study only.

✦ Synopsis

An approach based on disposition decomposition analysis (DDA) and the hysteresis minimization principle has been developed for pharmacodynamic modeling. It allows calculation of the mean transit time and the ratio of distribution clearance to biophase distribution volume of drug, and determination of the drug concentration-time function at the biophase (Cb(r)). The proposed method extends the DDA approach to drug distribution to a possibly heterogeneous effect compartment of a generalized pharmacokinetic/pharacodynamic model. The application of this DDA-dynamics method is demonstrated using published data for pancuronium.

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