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Disposition and metabolism of bruceantin in the mouse

โœ Scribed by William J. Suling; Carolyn W. Woolley; William M. Shannon

Book ID
112287047
Publisher
Springer
Year
1979
Tongue
English
Weight
532 KB
Volume
3
Category
Article
ISSN
0344-5704

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The pharmacokinetics and metabolism of pyrazine-2-diazohydroxide have been studied in the beagle dog and mouse. When pyrazine-2-diazohydroxide was administered to beagle dogs at a dose of 18.6 mg/kg (428 mg/m2) by i.v. bolus, the plasma half-life (t1/2) was 7.3 min, the apparent volume of distributi