Disparity in FcεRI-Induced Degranulation of Primary Human Lung and Skin Mast Cells Exposed to Adenosine

Comparison of FcϵRI- and FcγRI-mediated

Comparison of FcϵRI- and FcγRI-mediated degranulation and TNF-α synthesis in human mast cells: selective utilization of phosphatidylinositol-3-kinase for FcγRI-induced degranulation

✍ Yoshimichi Okayama; Christine Tkaczyk; Dean D. Metcalfe; Alasdair M. Gilfillan 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 318 KB

## Abstract We have demonstrated that CD34^+^ IFN‐γ‐treated human mast cells (HuMC) express functional FcγRI and that aggregation of these receptors leads to mediator release. As the signaling pathways linking FcγRI aggregation to mediator release are unknown, we examined FcγRI‐dependent activation