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Disparate folding and stability of the ankylosing spondylitis–associated HLA–B*1403 and B*2705 proteins

✍ Scribed by Elena Merino; Begoña Galocha; Miriam N. Vázquez; José A. López De Castro


Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
630 KB
Volume
58
Category
Article
ISSN
0004-3591

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HLA-B27 molecules are interesting because of their strong association with ankylosing spondylitis (AS) and reactive arthritis (ReA). A pathogenetic role for these molecules has been postulated in presenting a putative "arthritogenic" peptide to CD8 T cells. The HLA-B\*2709 subtype, although differin