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Disparate cleavage of poly-(ADP-ribose)-polymerase (PARP) and a synthetic tetrapeptide, DEVD, by apoptotic cells

✍ Scribed by K. Yu; C.A. Kennedy; M.M. O'Neill; R.W. Barton; R.J. Tatake

No coin nor oath required. For personal study only.

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Scheme 1. A) Opposing roles of PARP-1 in necrotic and apoptotic death. B) Chemical quantitation of NAD + .