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Disopyramide and its N-monodesalkyl metabolite in breast milk.

✍ Scribed by DB Barnett; SA Hudson; A McBurney

Book ID
117942918
Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
319 KB
Volume
14
Category
Article
ISSN
0306-5251

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Comparative class 1 electrophysiologic and anticholinergic effects of disopyramide and its main metabolite (mono-N-dealkylated disopyramide) in healthy humans
✍ Lennart Bergfeldt; Karin Schenck-Gustafsson; Rune Dahlqvist πŸ“‚ Article πŸ“… 1992 πŸ› Springer US 🌐 English βš– 860 KB

During steady-state treatment with disopyramide, its main and active metabolite, mono-N-dealkylated disopyramide, was reported to reach concentrations that were equal to or higher than the parent drug in 25% of 70 evaluated patients. This metabolite has been found to have a more pronounced anticholi