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Disentangling the perturbational effects of amino acid substitutions in the DNA-binding domain of p53

โœ Scribed by A. I. Wacey; D. N. Cooper; D. Liney; E. Hovig; M. Krawczak


Publisher
Springer
Year
1999
Tongue
English
Weight
88 KB
Volume
104
Category
Article
ISSN
0340-6717

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## Abstract Molecular interaction between p53 tumor suppressor and the copper protein azurin (AZ) has been demonstrated to enhance p53 stability and hence antitumoral function, opening new perspectives in cancer treatment. While some experimental work has provided evidence for AZ binding to p53, no